Bio-X Frontiers in Interdisciplinary Biosciences Seminar, "Molecular Structural Basis for Amyloid Formation in Alzheimer's Disease"

May 07, 2015 (Thu) | 12:00 PM -1:05 PM
James H. Clark Center, 318 Campus Drive, Seminar Room S360 : Stanford, CA

Lunch to be served at 12:00PM; seminar begins at 12:15PM. Abstract: In Alzheimer's disease (AD), the amyloid-β (Aβ) peptide spontaneously aggregates in brain tissue to form amyloid fibrils and other types of supramolecular assemblies, which are a likely primary cause of neurodegeneration. Detailed molecular structural information for Aβ fibrils can help us understand the Aβ self-assembly process, contribute to our understanding of pathogenic mechanisms, and guide the development of drugs and imaging agents. In this lecture, I will describe the highlights of my labís studies of amyloid structures, beginning with investigations of β-sheet organization in fibrils formed in vitro and culminating in structural studies of fibrils derived from AD brain tissue.

Department:  BioX

Contact: Christina Huber | 650-725-7472 | chuber@stanford.edu

Presenter(s):

        Course Website