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Cancer initiation and progression are controlled by the interplay between tumor, stromal and immune cells. I will describe the use of highly multiplexed immunofluorescence imaging and micro-region transcriptomics to understand the molecular and spatial diversity of immune-tumor interactions. In the case of early melanomas, a wide diversity of states can be identified in a single resection. These range from cancer precursor cells to melanoma in situ to fields in which tumor cells have successfully been immunoedited. Comparison of these states reveals principles of immune evasion and its potential reactivation for therapeutic purposes.

Department:  Biomedical Data Sciences Department

Contact: Pornprang Plangsrisakul | 6507215338 | pplangs@stanford.edu

Presenter(s):

• Peter Sorger, PhD Otto Krayer Professor & Head of HiTS, Harvard Medical School

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